A sustainable approach towards the three-component synthesis of unsubstituted 1H-imidazoles in the water at ambient conditions

Abstract

A green protocol for the synthesis of unsubstituted imidazoles has been demonstrated herein. The reaction is realized using commercially available lipase enzyme, porcine pancreas lipase (PPL) in water. The reaction conditions are selective and mild which helped to tolerate a wide variety of functional groups to give the desired products in good chemical yields.

Graphical Abstract

Keywords:

• Imidazole
• aldehyde
• ammonium acetate
• lipase

Acknowledgements

The spectral data were obtained from the Institute of Chemical Technology, Mumbai.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

SSK and HKC are thankful to TEQIP III CoE-PI, India for financial support.