Two new milbemycin derivatives from a genetically engineered strain Streptomyces bingchenggensis

Abstract

Two new milbemycin derivatives, milbemycin M (1) and milbemycin N (2), were isolated from the culture of a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with previous reports. The acaricidal and nematicidal activities of them against Tetranychus cinnabarinus and Bursaphelenchus xylophilus were tested. The results showed that compounds 1–2 possessed potent acaricidal and nematocidal activities.

Graphical Abstract

Keywords:

• Genetically engineered strain
• Streptomyces bingchenggensis BCJ60
• milbemycin derivatives
• acaricidal and nematocidal activities

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Science and Technology Project of Taizhou [No. 1801gy24], the Zhejiang Provincial Natural Science Foundation of China [No. HX2019069 and HX2019078] and the Key Research and Development Program of Zhejiang Province (No. 2020C02028 and 2019C02030).