1,10-seco guaianolide-type sesquiterpenoids from Chrysanthemum indicum

ABSTACT

A chemical investigation of the whole plant of traditional Chinese medicine, Chrysanthemum indicum L., led to the discovery of six guaianolide-type sesquiterpenoids 1–6 with a 1,10-splited skeleton. The structure of the new compound 1 was established by extensive analysis of UV, IR, MS, NMR and ECD data. Compounds 3–6 are mutually stereoisomers with four chiral centers and their absolute configurations were determined by comparison of ECD spectra. The anti-inflammatory effects of these isolates on lipopolysaccharide (LPS)-induced nitric oxide (NO) were investigated in RAW 264.7 cells. Results showed that most of the compounds displayed NO production inhibitory activities with IC₅₀ values ranged from 3.54 to 8.17 μM.

Graphical abstract

Keywords:

• Chrysanthemum indicum
• 1,10-seco-guaianolide
• sesquiterpenoid
• anti-inflammation

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The financial support from the Central Government Guide Local Science and Technology Development Funds (No.14104349), the National Natural Science Foundation of China (No.31300284), and Scientific and Technological Key Project in Henan Province (No.192102310438).