https://orcid.org/0000-0003-0099-1118
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Abstract
Previous work has shown that the lignans from the twigs and leaves of Archidendron clypearia (Jack) I.C.N. possess anti-β-amyloid aggregation activity. Here we report a new dilignan, archidendronin A (1), along with one known sesquilignan (2). Their structures were determined by extensive spectroscopic methods, including UV, HRESIMS, 1 D and 2 D NMR data. The inhibitory activity on Aβ1-42 aggregation was screened by ThT assay with curcumin as the positive control, and compounds 1 and 2 showed inhibition rate of 60.0% and 64.4% at 20 μM, respectively.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China (81502954) and the Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006) and the Project of Innovation Team Foundation (LT2015027).
