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Abstract
A new indolizinium alkaloid, named as cyclizidine J (1), was identified from Gause’s liquid fermentation of marine-derived Streptomyces sp. HNA39. Its structure was elucidated by extensive NMR spectroscopic methods, HRESIMS data, and ECD calculations. To our best knowledge, compound 1 was a unique cyclizidine-type alkaloid that contain a chlorine atom substituted at position C-8. Unfortunately, biological evaluation of 1 exhibited no active against PC-3 cancer cell line, BRD4, and ROCK2 protein kinase.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
This work was financially supported by the Fundamental Research Funds for the Central Universities [2018QNA4043].