Synthesis and biological activity of pyridine acylhydrazone derivatives of isopimaric acid

Yan-Ju Lua Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing210042, China;b National Engineering Lab. for Biomass Chemical Utilization, Nanjing210042, China;c Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, Nanjing210042, China;d Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing210042, China;e Key Lab. of Biomass Energy and Material, Nanjing210042, China;f Research Institute of Forestry New Technology, Chinese Academy of Forestry, Beijing100091, ChinaCorrespondence[email protected]
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Zhen-Dong Zhaoa Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing210042, China;b National Engineering Lab. for Biomass Chemical Utilization, Nanjing210042, China;c Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, Nanjing210042, China;d Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing210042, China;e Key Lab. of Biomass Energy and Material, Nanjing210042, China;f Research Institute of Forestry New Technology, Chinese Academy of Forestry, Beijing100091, ChinaCorrespondence[email protected]
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Yu-Xiang Chena Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing210042, China;b National Engineering Lab. for Biomass Chemical Utilization, Nanjing210042, China;c Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, Nanjing210042, China;d Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing210042, China;e Key Lab. of Biomass Energy and Material, Nanjing210042, China;f Research Institute of Forestry New Technology, Chinese Academy of Forestry, Beijing100091, ChinaView further author information

Jing Wanga Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing210042, China;b National Engineering Lab. for Biomass Chemical Utilization, Nanjing210042, China;c Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, Nanjing210042, China;d Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing210042, China;e Key Lab. of Biomass Energy and Material, Nanjing210042, China;f Research Institute of Forestry New Technology, Chinese Academy of Forestry, Beijing100091, ChinaView further author information

Shi-Chao Xua Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing210042, China;b National Engineering Lab. for Biomass Chemical Utilization, Nanjing210042, China;c Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, Nanjing210042, China;d Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing210042, China;e Key Lab. of Biomass Energy and Material, Nanjing210042, China;f Research Institute of Forestry New Technology, Chinese Academy of Forestry, Beijing100091, ChinaView further author information

Yan Gua Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing210042, China;b National Engineering Lab. for Biomass Chemical Utilization, Nanjing210042, China;c Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, Nanjing210042, China;d Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing210042, China;e Key Lab. of Biomass Energy and Material, Nanjing210042, China;f Research Institute of Forestry New Technology, Chinese Academy of Forestry, Beijing100091, ChinaView further author information

Abstract

Pyridine acylhydrazone derivatives of isopimaric acid were synthesized and characterized. The minimum inhibitory concentrations of the compounds against five bacteria were determined and most of the compounds displayed some degree of antibacterial activity. The results showed that antimicrobial activity against Streptococcus pneumoniae improved when halogen atoms were introduced into the isopimaric acid, especially when one bromine atom was introduced in the para-position of isopimaric acid. Compound isopimaric acid (5-bromo pyridine-2-formaldehyde) acylhydrazone exhibited a significant antitumorial activity against hepatocarcioma cells (HepG-2) and breast cancer cells (MDA-MB-231), with inhibition degrees of 74.21% and 70.39%, respectively, at 100 μM.

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This research was supported by the National Natural Science Foundation of China (grant No. 31700504) and the Fundamental Research Funds of Jiangsu Province Biomass Energy and Materials Laboratory, China (grant No. JSBEM-201808).

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Synthesis and biological activity of pyridine acylhydrazone derivatives of isopimaric acid

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Synthesis and biological activity of pyridine acylhydrazone derivatives of isopimaric acid

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