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Original Articles

A new prenylated coumarin diglycoside with insulin-release promoting activity from Clausena dunniana

, , , , , , & show all
Pages 385-391 | Received 07 May 2020, Accepted 11 Aug 2020, Published online: 30 Aug 2020
 

Abstract

A new prenylated coumarin diglycoside, 6-prenylcoumarin-7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and five known flavonoid glycosides (2–6) were isolated from the leaves and stems of Clausena dunniana. The structures of these isolates were elucidated based on comprehensive MS, UV, IR, and NMR spectroscopic data analysis and comparison with the data reported in literature. Compounds 2–6 are obtained from the title plant for the first time. All these isolates were evaluated for their insulin-release promoting effects, and compounds 1, 2, and 4 exhibited significant activities (2.0 to 3.3-fold higher in comparison with the control, p < 0.01) at 40 μM.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by National Natural Science Foundation of China [NSFC; grant numbers 81973199, 81773864, and 81473106) and The Drug Innovation Major Project of China (No. 2018ZX09711001-008-003).

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