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Abstract
There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives 7c-m with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine. In addition, derivative 7e enhanced the survival rate to 40% in the mouse model of the lethal EV71 infection.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
This study was funded by National Natural Science Foundation of China (81502918), the Drug Innovation Major Project (2018ZX09711-001-005), the Fundamental Research Funds for the Central Universities (2016ZX350015) and the National Science and Technology Major Project of the Ministry of Science and Technology of China (2018ZX09721003-008-026).