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Abstract
Two new compounds named epipaxilline (1) and penerpene J (2) were isolated from the marine-derived fungus Penicillium sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds 1 and 2 showed inhibitory activities against PTP1B with IC50 values of 31.5 and 9.5 μM, respectively, and compound 2 also showed inhibitory activities against TCPTP with IC50 value of 14.7 μM.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by Natural Science Foundation of Hainan Province (2019CXTD411), Natural Science Foundation of China (81973568, 41606088), China Agriculture Research System (CARS-21), Financial Fund of the Ministry of Agriculture and Rural Affairs, P. R. China (NFZX2018), Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (17CXTD-15, 1630052016008).