https://orcid.org/0000-0003-0099-1118
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Abstract
Chemical investigations of the 75% EtOH extract from the fruits of Crataegus pinnatifida led to the isolation of three undescribed naturally occurring sesquineolignans with two 8-O-4'-type neolignan moieties, cratapinnatifidas A-C (1–3). Their chemical structures were elucidated by the comprehensive spectroscopic analyses (HRESIMS, 1D and 2D-NMR). In the bioactivity assay, their cytotoxic activities against two human hepatoma cell lines (HepG2 and Hep3B) were evaluated and no significant activity was seen with IC50 values ranging from 12.5 to 50.0 μM.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006) and the Project of Innovation Team Foundation (LT2015027).