Generation of tryptamine derivatives through biotransformation by Diaporthe sp.

Abstract

Three new tryptamine derivatives diaporols T-V (1–3) were isolated by adding tryptamine into the culture of Diaporthe sp., a fungus obtained from the leaves of Rhizophora stylosa. The structures of these compounds were elucidated by NMR spectroscopy and high resolution mass spectroscopic data. Among them, compound 1 showed moderate cytotoxic activity against SW480 cancer cell with IC₅₀ 9.84 μM.

Graphical abstract

Keywords:

• Biotransformation
• Diaporthe sp.
• tryptamine
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the “The Natural Science Foundation of the Jiangsu Higher Education Institutions of China” (No.19KJD150004) and “The Natural Science Research Project of Wuxi Taihu University” (No.18WUNS003).