Abstract
A new flavonoid named (2S)-7,4′-dimethoxyl-6-(2″,3″-epoxy-3″-methylbutyl)flavanone (1), along with five known compounds (2–6), were isolated from the EtOAc-soluble extract of the stem bark of Maackia amurensis. Their structures were elucidated on the basis of spectroscopic methods. All compounds were evaluated for anti-inflammatory and antioxidant activities in vitro. Among them, compound 5 showed the highest inhibitory activity on NO production in RAW264.7 cells stimulated by LPS with IC50 value of 59.0 ± 1.5 µM. Meanwhile, compounds 1–6 exhibited varying antioxidant activities through DPPH, ABTS free radical-scavenging and FRAP assays.
Graphical abstract
Acknowledgements
We thank to the workers of Kunming Biotechnology Co., Ltd, and the colleagues of the Research Center for Chemistry, Guangzhou University of Chinese Medicine.
Disclosure statement
No potential conflict of interest was reported by the authors.