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Abstract
Two new flavonoid glycosides named 6-hydroxy-3-methoxy-apigenin 7-O-α-ʟ-rhamnopyranoside (1) and 3-hydroxyl-apigenin 8-C-β-ᴅ-xylopyranoside (2), along with five known compounds (3-7), were isolated from Xanthium strumarium. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All compounds were evaluated for in vitro inhibitory activity against PTP1B. Among them, compounds 1 and 5 showed significant inhibitory activity on PTP1B with IC50 values of 11.3 ± 1.7 and 8.9 ± 0.7 μM, respectively.
Graphical abstract
Acknowledgements
The authors wish to express thanks to the First People’s Hospital of Yongkang for providing a research grant and the Department of Instrumental Analysis of Wenzhou Medical University for the measurement of the UV, IR, HREIMS and NMR.
Disclosure statement
No potential conflict of interest was reported by the authors.
