Two new polyketides from endophytic fungus Pestalotiopsis sp. HQD-6 isolated from the Chinese mangrove plant Rhizophora mucronata

Abstract

Mangrove endophytic fungi were proved to be a prolific resources for bioactive secondary metabolites. Two new polyketides, pestalotiopin B (1) and pestalotiopyrone N (2) were obtained from the ethyl acetate extracts of the rice solid cultures of the mangrove endophytic fungus Pestalotiopsis sp. HQD-6. The structures of 1 and 2 were determined by detailed interpretation of NMR spectroscopic analysis and HR-ESIMS. All of the isolates were evaluated for their antimicrobial, antioxidant and cytotoxic activities.

Graphical abstract

KEYWORDS:

• Mangrove endophytic fungi
• Pestalotiopsis sp.
• polyketides
• structure identification

Disclosure statement

No potential confliction of interest was claimed.

Additional information

Funding

This work was financially supported by the High-level Talents Programs of Hainan Province (2019RC006), Key Science and Technology Project of Hainan Province (ZDKJ202018), National Natural Science Foundation of China (No. 81973229/81660584) and Key Project of Education Department of Hainan Province (Hnky2019ZD-6).