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Abstract
Two new sesquiterpene aryl esters, armimelleolides A and B (1 and 2), and four known ones, were isolated from the EtOAc extract of Armillaria gallica 012 m by column chromatography on silica gel, reversed-phase C18 silica gel and semi-preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods, including extensive 1 D NMR, 2 D NMR and MS. All these compounds showed potential antitumor activities against at least one of the human cancer cell lines (A549, HCT-116, M231 and W256), with IC50 ranging from 2.57 to 19.94 μM.
Graphical abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This project was in part supported financially by the National Natural Science Foundation of China (Nos.31760096, 31960095, 81660717, and 81960777), Yunnan Ten-thousand Talents Program to W.-G.W., the National Natural Science Foundation of Yunnan Provinces (No. 2019FB027). Yunnan Provincial Science and Technology Department–– Applied Basic Research Joint Special Funds of Yunnan University of Traditional Chinese Medicine [grant number 2019FF002(-005), 2018FF001(-029)].
