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Abstract
Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of Hypericum genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C (1) and hyperacmosin D (2) were isolated from H. acmosepalum. Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra. Besides, compound 1 showed significant hepatoprotective activity at 10 µM against paracetamol-induced HepG2 cell damage and compound 2 could moderately increase the relative glucose consumption.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This research was funded by Projects of International Cooperation and Exchanges NSFC (NSFC-VR, No. 81361138020), National Science and Technology Major Projects for “Major New Drugs Innovation and Development”, Research and Development of New Drug Varieties from Natural Product Sources and Their Key Innovative Technological Systems (No. 2018ZX09711001-001-001 and 2018ZX09711001-001-003) and the CAMS Innovation Fund for Medical Sciences (CIFMS), the CAMS Initiative for Innovative Medicine (CAMS-I2M, No. 2016-I2M-1-010).