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Abstract
Phytochemical investigation on the roots of Aconitum pseudostapfianum resulted in the isolation of three new aconitine–type C19–diterpenoid alkaloids, pseudostapines A–C (1–3). Their structures were determined by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, NOESY and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vivo for their antinociceptive potential. As a result, pseudostapine C (3) showed 2-fold more potent antinociceptive effect (ID50 = 60.3 μmol/kg) than the positive control drugs aspirin and acetaminophen.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was funded by the joint special fund project of the Applied Basic Research for local university in Yunnan Province [2019FH001(-033)], Special funds for reform and development of local university supported by the Central Finance (PL201707230369), and the National Undergraduate Training Programs for Innovation and Entrepreneurship (201910684029).