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Abstract
Three previously unidentified polycyclic polyprenylated acylphloroglucinols (PPAPs) derivatives, hypseudohenrins I–K (1–3), along with a known analogue hyphenrone X (4), were isolated from the aerial part of Hypericum pseudohenryi. The structures of the new compounds were elucidated by NMR spectroscopy and ECD calculation. The anti-inflammatory activity of the compounds was evaluated. Compounds 1–3 showed mild anti-inflammatory activity while hyphenrone X showed prominent anti-inflammatory activity.
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Disclosure statement
The authors declare no compete in financial interests.
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Funding
This work was financially supported by Projects of International Cooperation and Exchanges NSFC (NSFC-VR, No. 81361138020), National Science and Technology Major Projects for “Major New Drugs Innovation and Development,” Research and Development of New Drug Varieties from Natural Product Sources and Their Key Innovative Technological Systems (No. 2018ZX09711001-001-001, 2018ZX09711001-001-003 and 2018ZX09711001-008-009) and the CAMS Innovation Fund for Medical Sciences (CIFMS), the CAMS Initiative for Innovative Medicine (CAMS-I2M, No. 2016-I2M-1-010).