Renoprotective activity of a new amide and a new hydroxycinnamic acid derivative from the fresh roots of Rehmannia glutinosa

Abstract

A new amide, named rehmagluamide (1), and a new hydroxycinnamic acid derivative, named nepetoidin F (2), together with six known compounds, 2′-O-methyluridine (3), puroglutamic acid (4), biliverdic acid (5), peterolactam (6), nicotinic acid (7), nicotinamide (8), were isolated from the fresh roots of Rehmannia glutinosa. All the structures of compounds were identified by the interpretation of their spectroscopic data and comparison with those reported in the literatures. The protective effects of compounds 1–7 on normal rat kidney tubule epithelioid (NRK-52e) cells injury induced by LPS were investigated. The results indicated that compounds 1, 2, and 7 exhibited protective effects against LPS-induced NRK 52e cells injury.

Graphical Abstract

Keywords:

• Scrophulariaceae
• fresh Rehmannia glutinosa
• amide
• hydroxycinnamic acid derivative
• NRK-52e cells

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

This research was funded by The Major Science and Technology Projects in Henan Province: (171100310500) and the National Key Research and Development Project (2017YFC1702800).