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Articles

A new 26-norlanostane from Phlogacanthus turgidus growing in Vietnam

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Pages 196-202 | Received 23 Dec 2020, Accepted 30 Mar 2021, Published online: 20 Apr 2021
 

Abstract

Chemical investigation on chloroform extract of Phlogacanthus turgidus led to the isolation of one new compound namely turgidol, together with five known triterpenoids, lupeol, lupenone, betulin, betulinic acid, and taraxerol. Their structures and stereochemistry have been determined by 1 D and 2 D NMR analysis, high resolution mass spectrometry, and compared with those in literatures. The relative configuration of turgidol was defined using DFT-NMR chemical shift calculations and subsequent DP4+ probability method. Turgidol, betulin, and betulinic acid were evaluated for cytotoxic activity toward K562 cancer cell line and the alpha-glucosidase inhibition.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is funded by Vietnam Academy of Science and Technology (VAST) under grant number VAST 04.06/19-20.

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