Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1

Abstract

Two new polyketides, palitantins B and C (1 and 2), along with one known related compound (+)-palitantin (3) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC₅₀ value of 7.9 μM (ursolic acid as positive control, IC₅₀ = 8.3 μM).

Graphical Abstract

Keywords:

• Geomyces sp.
• polyketide
• PTP1B inhibitory activity

Disclosure statement

The authors declared that they have no conflicts of interest to this work.

Additional information

Funding

This research was financially supported by the National Key Research and Development Program of China (Nos. 2018YFC1406705 and 2018YFC0310900), the Shanghai Pujiang Program (No. 2020PJD082), the Natural Science Foundation of Shanghai (No. 20ZR1470600), and the National Natural Science Foundation of China (Nos. 41606173 and 81741152).