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Abstract
Five new denudatine-type diterpenoid alkaloids (1–5), along with the known analogue aconicarmine (6), were isolated from an aqueous decoction of the lateral roots of Aconitum carmichaelii (fu-zi). Their structures were determined by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Compound 5 is the first denudatine-type diterpenoid alcohol iminium alkaloid, which could be partially transformed into the aza acetal form in pyridine-d5. Compound 5 inhibited mice writhing in an acetic acid-induced writhing assay.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
Financial support from the National Natural Sciences Foundation of China (grant nos. 81630094 and 21732008), CAMS Innovation Fund for Medical Science (2017-I2M-3-010), and The Drug Innovation Major Project (2018ZX09711001-001) is acknowledged.