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Abstract
On our ongoing searching for bioactive natural products derived from entophytes, two polyketides possessing novel skeletons, alternatones A–B (1–2), were identified from the culture of Alternaria alternate L-10. Their structures were established by a combination of spectroscopic and single-crystal X-ray diffraction with Cu Ka radiation. Alternatone A (1) exhibited cytotoxic activity against human hepatoma carcinoma HepG-2 cell line. The putative biosynthetic pathways for compounds 1–2 were also proposed.
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Disclosure statement
These authors have no conflict of interest to declare.
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Funding
This work was financially supported by MOST of China (2018YFA0902000, 2018YFC1706200 and 2019YFC0312500), Jiangsu Provincial Research Foundation for Basic Research, China (Grant No. BK 20180333), the National Natural Science Foundation of China (81903483).
