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Articles

Antimicrobial alkaloids from the root bark of Dictamnus dasycarpus

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Pages 483-489 | Received 22 Mar 2021, Accepted 02 Jun 2021, Published online: 30 Jun 2021
 

Abstract

Two new furoquinoline alkaloids, named 1'-oxo-isoplatydesmine (1) and demethoxyacrophylline (2), as well as 11 known alkaloids (3-13) were isolated from the root bark of Dictamnus dasycarpus Turcz. The structures of 1 and 2 were established by detailed spectroscopic elucidation, such as 1 D & 2 D NMR and HRMS, etc. The unexpected autoracemization of 1 was discussed based on the stereochemistry of reported dihydrofuroquinolines. Compounds 3–5 exhibited moderate inhibitory activities against Bacillus subtilis, Candida albicans, and Pseudomonas aeruginosa with MICs 32–64 μg/ml, revealing the active principles of D. dasycarpus for treating skin diseases in its traditional usage.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Drug Innovation Major Project of China (NO. 2018ZX09711-001-001-001 and 2018ZX09711-001-001-003).

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