Abstract
Ornithogalum caudatum Ait (OCA) is a natural product used in Chinese traditional medicine. The cholestane saponin OSW-1 is isolated from plant OCA and has recently been shown to have potent cytotoxic effects against different types of cancers. The therapeutic efficacy of OSW-1 on prostate cancer and its underlying mechanism are yet to be established. OSW-1 inhibited the growth of prostate cancer cells by interrupting the interaction between mTOR and Rictor/mTORC2. This mechanism showed a better therapeutic outcome than that of the conventional inhibition of mTOR and provided a basis for as sisting modern prostate cancer treatment strategies.
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Acknowledgments
Nanjing Sky Technology Co. Ltd. for supporting this study.
Disclosure statement
The author declares no conflict of interest.
Funding
This study was supported by Nanjing Sky Technology Co. Ltd [AG/NST001].
Data availability
All presented data in this research are included in the study.