Chemical constituents from the aerial parts of Saussurea involucrata with their inhibitory activities on α-glucosidase

Abstract

A new aurone glycoside named licoagroaurone 6-O-α-ʟ-arabinopyranoside (1), together with six known compounds (2–7), was isolated from EtOAc-soluble extract of the aerial parts of Saussurea involucrata. Their structures were elucidated on the basis of spectroscopic methods. All compounds were evaluated for their inhibitory activities against α-glucosidase in vitro. Among them, compounds 1 and 6 showed significant inhibitory activities on α-glucosidase with the IC₅₀ values of 47.1 and 57.7 μM, respectively.

Keywords:

• Saussurea involucrata
• Araliaceae
• aurone glycoside
• α-glucosidase

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was financially supported by grants from the Key Natural Science Foundation of Bengbu Medical College (No. BYKY2019003ZD) and Bengbu Innovation of Science and Technology Project (No. 20200332).