Antimicrobial mexicanolide limonoids from the seeds of Khaya senegalensis

Abstract

Three new mexicanolide limonoids were obtained from the 90% ethanol extract of the seeds of Khaya senegalensis. Their structures were elucidated as senegalenines A–C (1–3) by analysing their 1D/2D NMR and MS spectroscopic analysis. In addition, the isolated limonoids were tested in vitro for antimicrobial potentials against 5 pathogenic microorganisms. Consequently, compounds 1–3 exhibited antimicrobial activity against the tested Gram negative bacteria at the minimum inhibitory concentration values less than 40 μg/ml.

Keywords:

• Khaya senegalensis
• Meliaceae
• mexicanolide limonoids
• antimicrobial activity

Disclosure statement

No potential conflict of interest was reported by the authors.