https://orcid.org/0000-0002-0218-307X
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Abstract
Three new polyketide derivatives, 2-ethoxycarbonyl-endocrocin (1), 6-methoxy-2-ethoxycarbonyl-endocrocin (2) and pannorin C (3), along with sixteen known compounds (4–19) were isolated from a plant endophytic fungus Aspergillus cristatus 2H1. Their structures were elucidated by 1D/2D NMR and HR-ESI-MS data analysis. Compound 3 showed weak antibacterial activity against Staphylococcus aureus (MIC 20 μg/ml). Compounds 14 and 15 showed effective cytotoxicity on human melanoma A375 cells (IC50 4.13 μM for 14, 3.39 μM for 15).
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Disclosure statement
These authors have no conflict of interest to declare.
Additional information
Funding
This work was sponsored by National Key R&D Program of China (2018YFC1706200), NSFC (81991524 and 82174089), and Qing Lan Project and Postgraduate Research & Practice Innovation Program (KYCX20_1610).