https://orcid.org/0000-0003-0099-1118
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Abstract
Ten compounds (1–10) including four new compounds (1–4) and six known compounds (5–10) were isolated from Solanum nigrum. Their structures were elucidated on the basis of spectroscopic data, gauge-including atomic orbital (GIAO) calculation of NMR data, DP4+ probability analysis and comparison of their experimental and calculated electronic circular dichroism (ECD) spectral data. All the isolated compounds were tested for their neuroprotective activities against H2O2-induced damage in SH-SY5Y cells. Among them, compounds 1, 5 and 7 displayed moderate neuroprotective effects.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006), Project funded by China Postdoctoral Science Foundation (2020M680987) and the Project of Innovation Team Foundation (LT2015027).