Synthesis of 1-substituted phenazines as novel antichlamydial agents

Abstract

A novel series of 1-substituted phenazines 4a-4l were designed and synthesized via Palladium-catalyzed reactions from 1-phenazine trifluoromethanesulfonate. These phenazines showed antichlamydial activity with IC₅₀ values from 1 to 10 μM. Among them, compounds 4c and 4i exhibited the best antichlamydial activity with IC₅₀ values from 2.06 to 2.74 μM without apparent cytotoxicity to host cells.

Graphical Abstract

Keywords:

• 1-substituted phenazine
• synthesis
• antichlamydial activity
• Palladium-catalyzed reactions

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (Grants No. 31400165 and 31370209), the Science and Technology Project Fund of Nantong City (JC2019097), and the fifth 226 High Level Talent Training Project of Nantong City.