Secondary metabolites with diversified structures from an endophytic fungus Colletotrichum gloeosporioides associated with a toxic medicinal plant Tylophora ovata

Abstract

Six new secondary metabolites, including two new nor-triterpenes (1 and 2), one new sesquiterpene (4), two new α-pyrone derivatives (6 and 7), and one new natural product (5) along with two known compounds (3 and 8) were isolated from an endophytic fungus Colletotrichum gloeosporioides obtained from a toxic medicinal plant Tylophora ovata. Their structures were elucidated by spectroscopic data analyses, while their absolute configurations were determined by CD and X-ray diffraction analyses. The in vitro anti-inflammatory activities of these compounds were evaluated.

Graphical Abstract

Keywords:

• Endophytic fungus
• Colletotrichum gloeosporioides
• nor-triterpenoids
• α-pyrones
• anti-inflammation

Acknowledgments

We are grateful to the Department of Instrumental Analysis, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College for measuring the IR, NMR, MS and HRESIMS.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was financially supported by grants from the National Natural Science Foundation of China [No. 21732008].