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Abstract
A new approach for the synthesis of the active barbatic acid has been achieved in eight steps with 22.3% total yield by using commercially available methyl atratate as starting material. This synthesis provides access to multi-gram quantities of barbatic acid with good purity for reference supplies and further analytical and toxicology investigations.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by the National Natural Science Fund of China (NNSFC 82160773), Guizhou Provincial Natural Science Foundation (QKH-J(2015)2019), the Natural Science Foundation of Guizhou Provincial Department of Education (QJH-KY[2021]068) and Natural Science Foundation of Guizhou University of Traditional Chinese Medicine (3040040210097).