Autophagy and pressure overload-induced cardiac hypertrophy

Abstract

Autophagy plays an important role in the pathogenesis of cardiovascular diseases. Dysregulation of autophagy may have a huge effect on cardiac hypertrophy induced by overload pressure although reports on autophagy and cardiac hypertrophy have been contradictory. Some studies showed that autophagy activation attenuated cardiac hypertrophy. However, others suggested that inhibition of autophagy would be protective. Different research models or different pathways involved could be responsible for it. Cardiac hypertrophy may be alleviated through regulation of autophagy. This review aims to highlight the pathways and therapeutic targets identified in the prevention and treatment of cardiac hypertrophy by regulating autophagy.

Graphical Abstract

Keywords:

• Autophagy
• overload-induced
• cardiac hypertrophy

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

National Natural Science Foundation of China (No.82104842); Youth Fund Project of the Natural Science Foundation of Hunan Province (No.2021JJ40416); Scientific Research Foundation of Education Department of Hunan Province (No.20C1404); Youth Fund Project of Hunan Traditional Chinese Medicine Science and Technology Plan (No.2021166).