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Abstract
Two new sesquiterpene dimers, lappadimers A and B, were isolated from the roots of Saussurea lappa (Yunmuxiang). Their structures were established on the basis of spectroscopic methods. They were found to have potential anti-inflammatory activity at 10 µM and could reduce LPS-induced NO levels in murine macrophage, with inhibitory rates of 67% and 47%, respectively.
Graphical Abstract
Acknowledgments
We are grateful for the financial support from the CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-1-028) and the Fund of Jiansheng Fresh Herb Medicine.
Declaration of competing interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Additional information
Funding
We are grateful for the financial support from the CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-1-028) and the Fund of Jiansheng Fresh Herb Medicine.