Five new compounds from Zingiberis Rhizoma Recens and their anti-apoptotic activity

Abstract

Five new compounds, named gingerol A (1a and 1b), gingerol B (2), diphenylheptane glycoside A (3) and diphenylheptane glycoside B (4), were isolated from the acetone extract of Zingiberis Rhizoma Recens. The structures of new compounds were elucidated on the basis of spectroscopic methods including UV, IR, 1D NMR, 2D NMR and HR-ESI-MS. Compounds 2–4 could significantly decrease the apoptosis rate and increase the survival rate of human normal lung epithelial cells (BEAS-2B) at the concentration of 10 μM.

Graphical Abstract

Keywords:

• Zingiberis Rhizoma Recens
• gingerol A (1)
• gingerol B (2)
• diphenylheptane glycoside A (3)
• diphenylheptane glycoside B (4)
• anti-apoptotic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

General Project of Henan Provincial Natural Science Foundation (212300410368); Henan TCM disciplinary research special subject (20-21ZY1040).