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Expeditious assembly of biuret-guanidine derivatives via the catalyst-free transformation

Zhen Yanga Department of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China;b Jilin Academy of Traditional Chinese Medical Science, Changchun 130021, ChinaView further author information

Ting-Ting Caoa Department of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China;c Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, ChinaView further author information

Yun-Fang Sunc Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, ChinaView further author information

Dao-Shun Wuc Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, ChinaView further author information

Yue Xua Department of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, ChinaView further author information

Shi-Hai Yanga Department of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, ChinaView further author information

Shu-Qin Wangb Jilin Academy of Traditional Chinese Medical Science, Changchun 130021, ChinaView further author information

Lei Wangc Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, ChinaCorrespondence[email protected]

https://orcid.org/0000-0002-5787-9795 View further author information

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Abstract

We disclose a mild and practical catalyst-free transformation for the expeditious construction of biuret-guanidine derivatives using aromatic isocyanates. This synthetic transformation is featured with mild reaction conditions and high efficiency.

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No potential conflict of interest was reported by the authors.

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Funding

This work was financially supported by the National Natural Science Foundation of China (81602977), the CAMS Basic and Innovation Fund for Medical Sciences (2019-RC-HL-010 and 2017-I2M-1-013), the Science and Technology Development Project of Jilin Province of China (20190304050YY).

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Expeditious assembly of biuret-guanidine derivatives via the catalyst-free transformation

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Expeditious assembly of biuret-guanidine derivatives via the catalyst-free transformation

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