Five new cyclopentenyl fatty acid derivatives from the seeds of Hydnocarpus anthelminthica

Abstract

Five new fatty acids with a terminal 3-oxo-cyclopentene ring, cyclopentenone acids A–E (1–5), were isolated from the ethanol extract of the seeds of Hydnocarpus anthelminthica. The structures of these compounds were elucidated on the basis of their spectroscopic data and chemical evidence. Compounds 1-3 were evaluated for their anti-inflammatory activity based on the inhibition of NO production in microglial BV2 cells, and all of them showed weak anti-inflammatory activities.

 

Keywords:

• Flacourtiaceae
• Hydnocarpus anthelminthica
• 3-oxo-cyclopentene ring
• enantiomers
• anti-inflammatory activity

Acknowledgments

The authors are grateful to the Department of Instrumental Analysis at our institute for the spectroscopic measurements.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 21732008).