Abstract
Two new azadirone-type limonoids, namely lasiocarpine A (1) and lasiocarpine B (2) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3–5). UV, IR, one- and two- dimensional NMR, and mass spectrometry were used to determine the chemical structure of the isolated compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, lasiocarpine A (1) showed the strongest activity with an IC50 value of 43.38 μM.
Graphical Abstract
![](/cms/asset/20b3aa99-0c5a-498a-9083-a99a8afd2b86/ganp_a_2032678_uf0001_c.jpg)
Acknowledgements
We thank to Mr. Kansi Haikal and Ms. Nurul Fadhilah at the Central Laboratory, Universitas Padjadjaran University for HRTOF-MS measurements and cytotoxic assay.
Disclosure statement
No potential conflict of interest was reported by the authors.