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Abstract
Quercetin is a plant-derived polyphenol flavonoid that has been proven to be effective for many diseases. However, the mechanism and in vivo metabolism of quercetin remains to be clarified. It achieves a wide range of biological effects through various metabolites, gut microbiota and its metabolites, systemic mediators produced by inflammation and oxidation, as well as by multiple mechanisms. The all-round disease treatment of quercetin is achieved through the organic combination of multiple channels. Therefore, this article clarifies the metabolic process of quercetin in the body, and explores the new pattern of action of quercetin in the treatment of diseases.
Graphical Abstract
Acknowledgments
We would like to thank Shimadzu (China), Co., Ltd. for technological support.
Disclosure statement
No potential conflict of interest was reported by the authors.
Author contributions
J.-D.J., Y.W. and N.-Z.X. conceived the task. A.K., L.-B.P., H.Y., J.F., P.H., Y.-F.L., S.A.and S.-R.M. performed the review and collected original studies. A.K., L.-B.P, H.X., Z.-W.Z, D.C., F.-Y.Y and M.-S.W. wrote the first draft of the manuscript. A.K., J.-D.J., Y.W. and N.-Z.X. revised the manuscript. Y.W. contributed to language editing and final revision. All data were generated in house, and no paper mill was used. All authors agree to be accountable for all aspects of the work ensuring integrity and accuracy.