Three new chromanes and one new flavone C-glycoside from Mallotus apelta

Abstract

Three new chromanes, malloapeltas J–L (1–3), and one new flavone C-glycoside, malloflavoside (4), together with four known compounds, apigenin 6-C-β-D-xylopyranosyl-8-C-α-L-arabinopyranoside (5), apigenin 6-C-β-D-glucopyranosyl-8-C-α-L-arabinopyranoside (6), apigenin 7-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (7), and acantrifoside E (8) were isolated from the methanol extract of the leaves of Mallotus apelta. Their chemical structures were determined using spectroscopic methods, including 1D, 2D NMR, and HR-ESI-MS methods. All the isolated compounds were evaluated their cytotoxic activity against human prostate cancer (PC-3) and human breast cancer (MCF-7) cells, but none of them showed cytotoxicities on both human cancer cell lines.

Graphical Abstract

Keywords:

• Mallotus apelta
• Euphorbiaceae
• chromane
• flavone C-glycoside
• malloapelta
• malloflavoside

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was financially supported by Vietnam Academy of Science and Technology (DL0000.01/19-20); The Ministry of Education, Science and Technology, Republic of Korea (Grant no. NRF-2021K2A9A1A06086013); and Korea Basic Science Institute (Grant no. C210300). High resolution mass data were obtained from Korea Basic Science Institute (KBSI, Chuncheon Center).