Hyperoside suppresses osteoclasts differentiation and function through downregulating TRAF6/p38 MAPK signaling pathway

Abstract

Hyperoside (HP), as a natural product, can promote proliferation and differentiation of osteoblasts and presents a protective effect on ovariectomized (OVX) mice. However, the inhibitory effect of HP on osteoclasts (OCs) and the potential mechanism remain to be elucidated. In this study, it was found that HP could effectively inhibit the differentiation and bone resorption of OCs, and its intrinsic molecular mechanism was related to the inhibition of TRAF6/p38 MAPK signaling pathway. Therefore, HP could be a promising natural compound for lytic bone diseases.

Graphical Abstract

Keywords:

• hyperoside
• osteoclast
• differentiation
• bone resorption
• TRAF6/p38 MAPK

Disclosure statement

The authors have no conflicting interests.

Additional information

Funding

This research was financially supported by the National Key R&D Program of China (2018YFC1708100); Guizhou Science and Technology Program (Qian Ke He Ji Chu ZK [2021] 520); Guizhou University Introduced Talent Research Project (Gui Da Ren Ji He Zi [2019] 29).