Sulfonated alkaloids from an aqueous extract of Isatis indigotica roots

Abstract

Eleven new sulfonated alkaloids (1 − 11) having diverse structures were isolated from an aqueous extract of the Isatis indigotica root (ban lan gen). Their structures were determined by spectroscopic data analysis, chemical method, and theoretical calculation, of which (−)-4 was proved by single crystal X-ray diffraction.

Keywords:

• Cruciferae
• Isatis indigotica
• sulfonated alkaloid
• isatithiomidosulfonate A
• isatindosulfonic acids
• isatithienopysulfonic acids

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial support from the National Natural Sciences Foundation of China (grant nos. 81630094 and 81730093) and CAMS Innovation Fund for Medical Science (2021-I2M-1-028) are acknowledged.