First total syntheses of kanjone and its natural analogues

Abstract

Kanjone (1), a bioactive furanoflavone and a potent biomolecule, was first isolated from Pongamia pinnata (L.). Herein, we have developed two approaches to synthesize kanjone as well as its natural analogues 6-methoxyisopongaglabol (2) and 6,3'-dimethoxy-[2″,3″:7,8]furanoflavone (3) starting from khellin and 3-hydroxy-4-methoxy-benzaldehyde, respectively.

Graphical Abstract

Keywords:

• Total synthesis
• natural product
• kanjone
• furanoflavone

Disclosure statement

The authors report there are no competing interests to declare.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (number 82003619) and the Open Research Fund of Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs (number 2021CC006).