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Abstract
Two new sesquiterpenoids, flammupin A (1) and flammupin B (2), along with two known compounds, enokipodin C (3) and 5,5'-dibuthoxy-2,2'-bifuran (4) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim. The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses. Compound 3 exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC50 values ranged from 3.69 to 11.84 μM.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by National Natural Science Foundation of China (No. 82073727), Innovation Capability Support Program of Shaanxi (No. 2018KJXX-044), Education Department of Shaanxi Provincial Government (No. 11JS009).