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Research Articles

Alkaloids from the stem of Ephedra equisetina

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Pages 238-244 | Received 23 Mar 2022, Accepted 09 May 2022, Published online: 25 May 2022
 

Abstract

Two new cyclotrypyamine alkaloids equisetinines A and B, as well as three known alkaloids (3–5) were isolated from the stems of Ephedra equisetina Bunge. Their structures were characterized by spectroscopic methods, and the absolute configurations of the new compounds were determined by interpretation of their electronic circular dichroism. Anti-asthmatic activities of compounds were evaluated by releasing β-Hex in C48/80-induced RBL-2H3 cells, and compound 5 exhibited significant anti-asthmatic activities.

Graphical Abstract

Disclosure statement

The authors have declared that there is no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.

Additional information

Funding

This research was financially supported by The National Key Research and Development Project (The Major Project for Research of the Modernization of TCM, No. 2019YFC1708800).

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