Bioactive compounds from Curcuma aeruginosa and the effect of comosone II on the migration and invasion of breast cancer cells

Abstract

Bioassay-guided separation afforded furanodienone 1,10-epoxide (9) as the new compound, curcolone (10) as partially described compound and ten known compounds; germacrone (1), furanodienone (2), curzerenone (3), curcumenol (4), zederone (5), comosone II (6), (1E,4E,8R)-8-hydroxygermacra-1(10),4,7(11)-trieno-12,8-lactone (7), 13-hydroxygermacrone (8), curcuzederone (11) and demethoxycurcumin (12). The study showed that germacrone, furanodienone, curzerenone, comosone II, 13-hydroxygermacrone, curcuzederone and demethoxycurcumin are the bioactive compounds of C. aeruginosa rhizomes. Comosone II significantly inhibited MDA-MB-231 cell migration and invasion through the inhibition of MMP-9 enzyme. The present study may lead to further anticancer studies of comosone II and supports the traditional uses of C. aeruginosa rhizomes.

Graphical Abstract

Keywords:

• Curcuma aeruginosa rhizomes
• Zingiberaceae
• triple-negative breast cancer cells MDA-MB-231
• comosone II
• cell migration and invasion
• matrix metalloproteinases

Disclosure statement

The authors declare no conflicts of interest in this study.

Additional information

Funding

The study was financially supported by the Ministry of Higher Education under the Fundamental Research Grant Scheme (FRGS/1/2019/STG04/USM/02/3).