Efficiency comparison of an isoeugenol-derivated compound, eugenosedin-A, with glibenclamide and pioglitazone in protecting cardiovascular dysfunction of diabetic SHR

Abstract

This study was to investigate three agents possible protective effect against DM-induced cardiovascular dysfunction in spontaneously hypertensive rats (SHR). Control group was fed normal diet, DM group was injected with STZ/NA and fed high fat diet (HFD), and treatment groups were given STZ/NA, fed HFD, and then oral gavaged with eugenosedin-A (Eu-A), glibenclamide (Gli), or pioglitazone (Pio) 5 mg/kg/per day for 4-week, respectively. Eu-A, Gli, and Pio clearly ameliorated the changes of body weight, cardiac weight, and the biochemical parameters, cardiovascular disorders and inflammation. Like Gli and Pio, Eu-A may be effectively to control DM and the cardiovascular dysfunction.

Graphical Abstract

Keywords:

• Eugenosedin-A
• glibenclamide
• pioglitazone
• diabetes mellitus
• cardiovascular dysfunction

Acknowledgments

We would also like to thank Ms. Tsui-Jung Lin for her technical advice and support.

Disclosure statement

The authors declare that there are no conflicts of interest.

Additional information

Funding

This work was financially supported by grants MOST 108-2320-B-276-002-MY3 to Dr. Kuo-Ping Shen from Ministry of Science and Technology, Taiwan, as well as VGHMHU109-001 to Dr. Kuo-Ping Shen from Kaohsiung Veterans General Hospital, Taiwan.