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Abstract
Two undescribed dammarane triterpenoid saponins, cypaliurusides O and P (1 and 2), were isolated from the ethanol extracts of the leaves of Cyclocarya paliurus. Bioactivity assay results showed that compound 1 has potential cytotoxic activities against selected human cancer cell lines in vitro, with IC50 values ranging from 14.55 ± 0.55 to 22.75 ± 1.54 µM. Compound 1 showed better antitumor activity against HepG2 cells with IC50 of 14.55 ± 0.55 µM. In addition, compound 2 showed no obvious antitumor activity.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This research was financially supported by the Natural Science Foundation of Guangxi Province [Grant 2018GXNSFAA281102], the Basic Ability Enhancement Program for Young and Middle-aged Teachers of Guangxi [Grant 2018KY0148].