Three new pyridine alkaloids and one new iridoid analogue from the leaves of Rehmannia glutinosa

Abstract

As part of an ongoing project on Rehmannia species, three new pyridine alkaloides (glutinosines A − C), and one new iridoid analogue (rehmaglutin E), were isolated from the leaves of Rehmannia glutinosa. The structures of the new compounds were established by extensive spectroscopic analysis and electronic circular dichroism calculations.

Graphical Abstract

Keywords:

• Scrophulariaceae
• Rehmannia glutinosa
• alkaloid
• iridoid

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by CAMS Initiative for Innovative Medicine [2021-1-I2M-028] and the State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College.