New polyketides from the basidiomycetous fungus Pholiota sp.

Abstract

Two new polyketides, pholiotones B and C (1 and 2), and four known compounds, trichodermatide D (3), vermistatin (4), dehydroaltenuene A (5) and terpestacin (6) were isolated from the crude extract of Pholiota sp. Their structures were identified by NMR and MS spectroscopic data. The absolute configurations of compounds 1 and 2 were elucidated by modified Mosher’s method, electronic circular dichroism (ECD) calculations and ¹³C NMR calculations as well as DP4+ probability analyses. All the compounds were evaluated for their antifungal and cytotoxicity.

Graphical Abstract

Keywords:

• Pholiota sp.
• structure elucidation
• biological activities

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

We gratefully acknowledge financial support from the National Natural Science Foundation of China (32022002 and 21977113).